Adjuvant HBOT and SWC are more effective than SWC in healing the DFUs and reduction of minor amputations.
Hyperbaric Oxygen Therapy Combined With Standard Wound Care Versus Standard Wound Care Alone in Patients With Diabetic Foot Ulcers: A Prospective Comparative Study.
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Abstract
Background Non-healing diabetic foot ulcers (DFUs) are significant risk factors for amputations. Though the available literature suggests that adjuvant hyperbaric oxygen therapy (HBOT) fastens the healing process and reduces the risk of amputations, its overall evidence in the reduction of amputation remains controversial. Thus, the present study aimed to compare the efficacy and safety of adjuvant HBOT and standard wound care (SWC) with SWC alone in patients with DFUs. Methods This prospective, randomized, controlled study involved 60 adult patients with DFU. Based on the simple random number table, the patients were equally randomized into two group: adjuvant HBOT and SWC (n=30) with SWC alone (n=30). The patients received 24 sessions (six sessions per week) of HBOT (3.0 absolute atmospheric pressure) for 45 minutes daily over a period of four consecutive weeks. The outcome measures included wound size reduction, wound bed condition, complications, and proportion of patients undergoing amputation. The patients were assessed at four-week follow-up. Results At four weeks, both the groups had a significant reduction in pain score, wound size, and inflammation of the surrounding skin compared to baseline (all p
Affiliation
Aldrin L Myrthong
External References
- PubMed ID:
- 39744274
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