Aged garlic extract and coenzyme Q10 have a beneficial effect on vascular elasticity and endothelial function in firefighters with high occupational stress.
Beneficial effects of aged garlic extract and coenzyme Q10 on vascular elasticity and endothelial function: The FAITH randomized clinical trial.
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Key Findings
Abstract
OBJECTIVE: Aged garlic extract (AGE) is associated with a significant decrease in atherosclerotic plaque progression and endothelial function improvement. Similarly, coenzyme Q10 (CoQ10) has significant beneficial effects on endothelial function. A stressful lifestyle is a well-known risk factor for the presence and progression of atherosclerosis. This study investigated the effect of AGE plus CoQ10 on vascular elasticity measured by pulse-wave velocity (PWV) and endothelial function measured by digital thermal monitoring (DTM) in firefighters. METHODS: Sixty-five Los-Angeles County firefighters who met the eligibility criteria were enrolled in this placebo-controlled, double-blinded randomized trial. The firefighters were randomized to four tablets of AGE (300 mg/tablet) plus CoQ10 (30 mg/tablet) or placebo. The participants underwent quarterly visits and 1-year follow-up. PWV and DTM were measured at baseline and at the 1-year follow-up. RESULTS: There were no significant differences in age, cardiovascular risk factors, PWV, and DTM between the AGE/CoQ10 and placebo groups at baseline (P>0.5). At 1-y, PWV and DTM significantly improved in the AGE/CoQ10 compared with the placebo group (P
Affiliation
Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, California, USA.
External References
- PubMed ID:
- 22858191
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