Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis.
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Abstract
BACKGROUND: Aged garlic extract with supplement (AGE-S) significantly reduces coronary artery calcium (CAC). We evaluated the effects of AGE-S on change in white (wEAT) and brown (bEAT) epicardial adipose tissue, homocysteine and CAC. METHODS: Sixty subjects, randomized to a daily capsule of placebo vs. AGE-S inclusive of aged garlic-extract (250mg) plus vitamin-B12 (100μg), folic-acid (300μg), vitamin-B6 (12.5mg) and l-arginine (100mg) underwent CAC, wEAT and bEAT measurements at baseline and 12months. The postcuff deflation temperature-rebound index of vascular function was assessed using a reactive-hyperemia procedure. Vascular dysfunction was defined according to the tertiles of temperature-rebound at 1year of follow-up. CAC progression was defined as an annual-increase in CAC>15%. RESULTS: From baseline to 12months, there was a strong correlation between increase in wEAT and CAC (r(2)=0.54, p=0.0001). At 1year, the risks of CAC progression and increased wEAT and homocysteine were significantly lower in AGE-S to placebo (p
Affiliation
Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA; Greater Los Angeles Veterans Administration Medical Center, UCLA-School of Medicine, Los Angeles, CA, USA. Electronic address: [email protected].
External References
- PubMed ID:
- 23453866
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