The ameliorative effect of Lactiplantibacillus plantarum SCS2 on DSS-induced murine colitis.
AI Summary
Key Findings
Abstract
The inhibitory effects of Lactiplantibacillus plantarum on inflammatory responses are known, but its action mechanisms in oxidative stress, immunomodulation, and intestinal homeostasis remain of interest. Accordingly, we investigated the protective effects of Lactiplantibacillus plantarum SCS2 (L. plantarum SCS2) against sodium dextran sulfate (DSS)-induced colitis in mice as well as elucidated its impact on inflammation, oxidative stress, and intestinal microbiota. The gut microbiota composition was analyzed by high-throughput 16S rDNA sequencing, and the levels of inflammatory cytokines and oxidative stress indicators in the colon were determined by quantitative polymerase chain reaction and biochemical analysis. The results revealed that pretreatment with L. plantarum SCS2 (10 × 10CFU/mL) attenuated DSS-induced pathological conditions such as colon shortening and weight loss in mice (P
Affiliation
Qian Luo
External References
- PubMed ID:
- 40920195
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.