Anethum graveolens could exert favorable effects on insulin resistance and serum LDL.

The effects of(dill) supplementation on lipid profile and glycemic control: a systematic review and meta-analysis of randomized controlled trials.

S H Mousavi, Ana Beatriz Pizarro, Camellia Akhgarjand, Abolqasem Bagheri, Emma Persad, Ehsan Karimi, Allison Wong, Ahmad Jayedi

Crit Rev Food Sci Nutr

Feb 24, 2021

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Abstract

There is an increased interest in the potential health benefits of nutraceutical therapies, such as(dill). Therefore, this systematic review and meta-analysis aimed to evaluate the effects ofsupplementation on lipid profiles and glycemic indices in adults. A systematic search was performed for literature published through November 2020 via PubMed/Medline, Scopus, ISI Web of Science, and Embase to find randomized controlled trials (RCTs) evaluating the effects of oral supplementation withon lipid profile and measures of glycemic control in adults. The random-effects model was applied to establish the weighted mean difference (WMD) and associated 95% confidence intervals (CI). Seven RCTs with a total number of 330 subjects were included in the final analysis. Pooled results indicated thatsupplementation significantly decreased low-density lipoprotein cholesterol (LDL) concentration (WMD: -15.64 mg/dL; 95% CI: -24.55 to -6.73; = 0.001), serum insulin (WMD: -2.28 μU/ml; 95% CI: -3.62 to -0.93; = 0.001), and HOMA-IR (WMD: -1.06; 95% CI: -1.91 to -0.20; = 0.01). However, there was no significant effect on serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL), and fasting blood glucose (FBS). Subgroup analysis suggested that usingin higher doses and long-term duration had beneficial effects on lipid profiles. Dose-response analysis also showed a significant reduction in FBS at doses of 1500 mg/d. The present meta-analysis indicated thatcould exert favorable effects on insulin resistance and serum LDL. Further research is necessary to confirm our findings.