Angelica sinensis polysaccharide improves neurological function and neuroplasticity following cerebral ischemia-reperfusion injury.
Low-Molecular-WeightPolysaccharide Improves Neurological Function and Neuroplasticity Following Cerebral Ischemia-Reperfusion Injury.
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Key Findings
Abstract
Neuroplasticity plays a pivotal role in post-stroke recovery, andpolysaccharide has demonstrated neuroprotective properties. This study investigated the neuroprotective effects of low-molecular-weightpolysaccharide (LMW-ASP) in a rat middle cerebral artery occlusion/reperfusion (MCAO/R) model. Structural characterization revealed that LMW-ASP (3.9 kDa), containing a pyranose ring and uronic acid, was a heteropolysaccharide that comprised fucose, galactosamine hydrochloride, rhamnose, arabinose, glucosamine hydrochloride, galactose, glucose, xylose, mannose, galacturonic acid, and glucuronic acid (0.007:0.003:0.057:0.209:0.009:0.284:0.303:0.006:0.032:0.083:0.007). Post-stroke administration of LMW-ASP (50 mg/kg) significantly improved body weight and neurological functions after MCAO/R. Moreover, microtubule-associated protein-2 expression was notably higher in the LMW-ASP group than in the model group (
Affiliation
Junbin Lin
External References
- PubMed ID:
- 41019183
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