An anthocyanin enriched extract of wild Chinese blueberry could effectively protect β-cells against glucolipotoxicity in vitro.
Anthocyanins-rich extract of wild Chinese blueberry protects glucolipotoxicity-induced INS832/13β-cell against dysfunction and death.
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Key Findings
Abstract
As commonly observed events in diabetic patients, glucolipotoxicity induces oxidative stress, apoptosis and functional defects inβ-cells. Anthocyanins are well investigated as strong antioxidants and modulators for metabolic syndromes. Therefore, this study examined the protective effects of anthocyanins-rich extracts (BAE) from wild Chinese blueberry (Vaccinium spp.) against glucolipotoxicity in β-cells. Results showed that INS832/13 β-cells subjected to glucolipotoxicity were significantly decreased (p 0.05) on BIS or TG. Additionally, TG levels reduced by BAE treatment were correlated with BIS (p
Affiliation
Jia Liu
External References
- PubMed ID:
- 25892804
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