Anti-asthmatic effects and ingredient annotation of the active fraction from Ganoderma lucidum.
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Key Findings
Abstract
This research aims to screen the active fraction and explore the action mechanism of Ganoderma lucidum to combat asthma using asthmatic mice induced by OVA. In this study, three Ganoderma lucidum fractions, including GLEF40, GLEF60, and GLEF100, were obtained through the separation of D101 macroporous adsorption resin. The result of the anti-asthmatic effects illustrated that GLEFs significantly reduce Th2- and Th1- cytokines, together with chemokines MIP-1αand MDC in bronchoalveolar lavage fluid (BALF) in asthmatic mice. Among the three fractions, GLEF100 demonstrated the most potent anti-inflammatory effect. Besides, GLEF100 significantly reduced IgE levels in asthmatic mice (P
Affiliation
Ning Li
External References
- PubMed ID:
- 41886154
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