Anti-neuroinflammatory and neuroprotective effects of caffeic acid.
Anti-Neuroinflammatory and Neuroprotective Effects of Caffeic Acid in Experimental Models of Neurodegeneration: A Systematic Review and Meta-Analysis.
AI Summary
Key Findings
Abstract
Caffeic acid, a naturally occurring polyphenol found in various dietary sources, has gained considerable interest for its antioxidant, anti-inflammatory, and neuroprotective properties. Preclinical studies suggest that caffeic acid may exert beneficial effects in models of Alzheimer's disease, Parkinson's disease, cerebral ischaemia, ageing, diabetes-associated cognitive decline, and neuroinflammation. To assess the neuroprotective activity of caffeic acid in neurodegenerative diseases. After performing a detailed literature search across various databases, such as Google Scholar, Embase, PubMed, Scopus, and Cochrane, a total of 44 unique studies were identified based on the framed eligibility criteria. This meta-analysis demonstrated that caffeic acid exerts significant effect on neurobiomarker panel: amyloid-βaccumulation (IV: -1.84 [-3.08, -0.61], 95% CI, p = 0.004, I= 8%), GFAP (IV: -2.03 [-2.91, -1.15], 95% CI, p
Affiliation
Radhika Bhat
External References
- PubMed ID:
- 42290548
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.