Anti-nociceptive and anti-inflammatory effects of hydroalcoholic extract and essential oil of Pinus eldarica in animal models.
Anti-nociceptive and anti-inflammatory effects of hydroalcoholic extract and essential oil ofin animal models.
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Abstract
Objective: Several species ofhave shown anti-nociceptive and anti-inflammatory properties. This study was aimed to evaluate anti-nociceptive and anti-inflammatory effects of hydroalcoholic extract of bark and essential oil of leaves ofin animal models. Materials and Methods: Hydroalcoholic extract of bark and essential oil of leaves ofwere prepared and phenolic content and essential oil composition were analyzed using Folin-Ciocalteu method and GC/MS, respectively. Anti-nociceptive effect was assessed using acetic acid, formalin and hot plate tests in male Swiss mice (25-30 g) and for evaluation of anti-inflammatory activity, carrageenan test in male Wistar rats (180-200 g) and croton oil-induced ear edema in male mice, were used. Involvement of opioid,α2-adrenergic, 5-HT3 receptors and adenosine triphosphate (ATP)-dependent K+ channels in pain relief was tested using naloxone, ondansetron, yohimbine and glibenclamide. Results: The total phenolic content of the extract in terms of gallic acid equivalent was 404.9±7.7 mg/g of the extract powder.hydroalcoholic extract (200 and 400 mg/kg) and essential oil (100 and 200µl/kg) significantly (all, p
Affiliation
Valiollah Hajhashemi
External References
- PubMed ID:
- 34745921
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