Antifungal Effects of Pterostilbene on Candida albicans, Candida dubliniensis, and Microcosm Biofilms of Denture Stomatitis.
Antifungal Effects of Pterostilbene on,, and Microcosm Biofilms of Denture Stomatitis.
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Key Findings
Abstract
Natural compound-based strategies have gained attention as alternatives to conventional antifungal therapies, particularly in the management ofinfections affecting the oral cavity, such as denture stomatitis. Our aim was to investigate the antifungal activity of the polyphenol pterostilbene (PTE) on clinicalisolates and microcosm biofilms from denture stomatitis, as well as to evaluate its toxicity and therapeutic efficacy in. PTE exhibited fungicidal effects againstandat 32µg/mL. Time-kill assays demonstrated complete inhibition of viability for both strains within 8 h of exposure. In addition, PTE exhibited broad-spectrum antimicrobial activity, significantly reducing the counts of streptococci,streptococci, staphylococci, and yeasts within microcosm biofilms. In vivo, PTE showed no signs of toxicity inat concentrations up to 20×MIC. Prophylactic treatment with PTE enhanced larval survival in experimental candidiasis caused by bothand. Moreover, prophylactic treatment decreased the fungal burden ofin thehemolymph, while the recruitment of hemocytes involved in host defense mechanisms remained unaltered. In summary, PTE demonstrated antimicrobial activity againstplanktonic cells and complex biofilms associated with denture stomatitis, exhibiting favorable biocompatibility and in vivo antifungal efficacy inmodel.
Affiliation
Paulo Henrique Fonseca do Carmo
External References
- PubMed ID:
- 41440696
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