Antimicrobial, anti-inflammatory, and wound healing properties of Myrtus communis leaf methanolic extract ointment on burn wound infection induced by methicillin-resistant Staphylococcus aureus.
Antimicrobial, Anti-inflammatory, and Wound Healing Properties ofLeaf Methanolic Extract Ointment on Burn Wound Infection Induced by Methicillin-Resistantin Rats.
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Key Findings
Abstract
MATERIALS AND METHODS: In a research experiment, 48 male Wistar rats were anesthetized and second-degree burns were induced on their backs. The rats' wounds were then uniformly inoculated with MRSA. Various treatments were applied to the burn wounds daily, including Myrtus ointment, silver nanoparticles, silver nanoparticles-Myrtus ointment, silver sulfadiazine-Myrtus ointment, silver sulfadiazine 1%, mupirocin ointment, and a positive control. The study measured the antimicrobial effects, wound area, percentage of wound healing, antioxidant capacities, malondialdehyde, and nitric oxide concentrations in the serum of the rats. Data analysis was performed using GraphPad software, with one-way ANOVA and Tukey's tests used to determine the statistical significance of the results. RESULTS: Rats treated with Myrtus ointment, silver nanoparticles-Myrtus ointment, and mupirocin had reduced bacterial growth compared to the positive control group, nanoparticle ointment, and silver sulfadiazine (
Affiliation
Zohre Jafari
External References
- PubMed ID:
- 38899039
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