Aspirin with or without chronic oral anticoagulant treatment does not reduce mortality or reinfarction, reduces stroke, but is associated with significantly more major bleeding.
Long-term effect of chronic oral anticoagulation with warfarin after acute myocardial infarction.
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Abstract
BACKGROUND: Antiplatelet therapy is the principal component of the antithrombotic regimen after acute myocardial infarction. It remains unclear whether additional chronic oral anticoagulation (OAC) improves outcomes. We set out to evaluate the risk and benefit of long-term OAC after myocardial infarction. METHODS: We pooled 10 randomized clinical trials comparing warfarin-containing regimens (OAC) with or without aspirin with non-OAC regimens with or without aspirin (No OAC) for patients with recent infarction. The primary endpoint was all-cause mortality. Other endpoints included recurrent infarction, stroke, and major bleeding. We calculated the odds ratio (OR) (fixed effect, OR
Affiliation
New York Methodist Hospital, Brooklyn, 11215, USA.
External References
- PubMed ID:
- 20193834
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