Assessment of the phytochemical profile, antioxidant capacity, and hepatoprotective effect of Andrographis paniculata.
Assessment of the Phytochemical Profile, Antioxidant Capacity, and Hepatoprotective Effect ofagainst CCl-Induced Liver Dysfunction in Wistar Albino Rats.
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Abstract
Recent studies have highlighted the necessity to thoroughly evaluate medicinal plants due to their therapeutic potential. The current study delves into the phytochemical profile, antioxidant capacity, and hepatoprotective effect ofThe investigation specifically targets its effectiveness in mitigating liver dysfunction induced by carbon tetrachloride (CCl) in Wistar albino rats, aiming to uncover its promising role as a natural remedy for liver-related ailments.leaf extract was screened for phytoconstituents and antioxidant and hepatoprotective effects in Wistar albino rats against CCl-induced liver dysfunction. Phytochemical analysis revealed the presence of flavonoids, alkaloids, and phenolic compounds in all extracts. The phenolic concentration ranged from 10.23 to 19.52 mg gallic acid per gram of the sample, while the highest flavonoid concentration was found in the ethanol fraction (8.27 mg rutin equivalents per gram). The antioxidant activity varied from 10.23 to 62.23. GC-MS analysis identified several phytochemicals including octadecanoic acid, stigmasterol, phenanthrenecarboxylic acid, and others. Effects of the ethanol extract ofwere evaluated in four groups of animals. Biochemical estimations of serum glutamine oxaloacetate transaminase, serum glutamine pyruvate transaminase, and serum bilirubin were significantly higher (
Affiliation
Syed Kashif Ali
External References
- PubMed ID:
- 37512069
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