The association between the Mediterranean diet and depression risk in postmenopausal women.
The association between the Mediterranean diet and depression risk in postmenopausal women: evidence from the UK Biobank cohort study.
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Abstract
BACKGROUND: Dietary strategies as non-pharmacological approach in mental health have attracted attention. The Mediterranean diet has been proven to reduce the risk of depression, yet evidence regarding its effect among postmenopausal women remains limited. This study aimed to examine the association between the Mediterranean diet and depression in postmenopausal women, and to examine interactions with age and menopausal timing. METHODS: The study utilized UK Biobank population-based cohort between 2006 and 2010. The Mediterranean diet was quantified using the PREDIMED score. Depression was identified through ICD-10 codes (F32, F33) from primary care records, hospital admissions, death registers and mental health questionnaire. Age at menopause less than 40 years was defined as premature ovarian insufficiency (POI). Cox proportional risk models estimated the hazard ratio (HR) for the onset of depression, with interaction effects for age and menopausal timing. The mediating effects evaluated C-reactive protein (CRP),γ-glutamyltransferase (GGT) and BMI roles. RESULTS: Among 58,001 women (mean follow-up 9.72 ± 1.57 years), 1457 developed depression. Compared with the lowest Mediterranean diet score, the risk of depression was reduced by 25% for the highest score (HR = 0.75, 95% CI: 0.63-0.89). Protective dietary components included olive oil, vegetables, seafood (P
Affiliation
Menglin Fan
External References
- PubMed ID:
- 41850610
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