Bamboo polyphenols protect against Salmonella enteritidis in chickens by modulating inflammation, barrier integrity, and microbiota.
Bamboo Polyphenols Protect AgainstEnteritidis in Chickens by Modulating Inflammation, Barrier Integrity, and Microbiota.
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Key Findings
Abstract
Enteritidis (SE) infections in poultry threaten animal health and food safety. Antibiotic resistance makes alternative treatments necessary. Bamboo polyphenols (BP), recovered from bamboo vinegar-a byproduct of bamboo carbonization-represent a sustainable and eco-friendly candidate for combating avian salmonellosis. We tested BP against SE using laboratory tests and a chick model. BP showed a minimum inhibitory concentration of 1:256 against SE. We infected chicks with 1.8×10CFU per bird. The results indicated that adding 0.2% (/) BP to drinking water demonstrated optimal efficacy for prevention. Adding 0.4% (/) BP demonstrated optimal efficacy for treatment. Prophylactic BP administration effectively prevented SE-induced mortality and tissue damage. As a therapeutic agent, BP performed comparably to berberine. BP lowered the bacterial load in organs and increased chick survival to 96%. At the transcriptional level, BP administration downregulated the TLR4/MyD88/NF-κB pathway. It also improved antioxidant levels, strengthened the intestinal barrier, and restored healthy gut bacteria. These results indicate that BP could serve as a potential and sustainable feed additive to reduce SE infection in poultry.
Affiliation
Qiaomei Liao
External References
- PubMed ID:
- 42121711
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