Betanin and vanillic acid reduce bleomycin-induced mitochondrial dysfunction in rat lung isolated mitochondria.
Betanin and vanillic acid reduce bleomycin-induced mitochondrial dysfunction in rat lung isolated mitochondria; a hormetic mode of action for vanillic acid.
AI Summary
Key Findings
Abstract
Mechanistic studies have been suggested that toxic effects of bleomycin are generally attributed to formation of free radicals, mitochondria damages, oxidative stress and inflammation. For this purpose, we explored the direct exposure of bleomycin and protective effects of the betanin and vanillic acid separately against its possible toxicity in rat lung isolated mitochondria. Various mitochondrial toxicity parameters were evaluated including; succinate dehydrogenases (SDH) activity, reactive oxygen species (ROS) formation, mitochondrial swelling, mitochondrial membrane potential (MMP) collapse, malondialdehyde (MDA) and glutathione disulfide (GSSG) levels. It was found that the direct exposure of isolated mitochondria with bleomycin (500 μM) resulted in a significant decrease of SDH activity (
Affiliation
Ahmad Salimi
External References
- PubMed ID:
- 40916635
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.