Bifidobacterium animalis subsp. lactis BL-16 fermented Astragali Radix (W16) promotes the bone growth.
subsp.BL-16 fermented(W16) promotes the bone growth of juvenile rats via modulation of IGF-1 and gut microbiota.
AI Summary
Key Findings
Abstract
INTRODUCTION: Short stature in children causes physical and psychological issues. Human growth hormone (hGH) is clinically recommended but has side effects. Probiotics and functional foods are promising alternatives., has growth-promoting potential, and fermentation may enhance its bioactivity. METHODS: , was fermented withsubsp.BL-16 to prepare postbiotic W16. Juvenile rats were treated with W16, hGH, or unfermented. UPLC-Q-TOF/MS metabolomic profiling, bone growth-related gene (,) expression, IGF-1 levels, glucose/insulin concentrations, and gut microbiota were analyzed. RESULTS: W16 enhanced rat body/bone length similarly to hGH, upregulated igf-1/trap, and increased plasma/liver IGF-1-more effectively than unfermented. Unlike hGH, W16 did not induce insulin resistance. While hGH andenriched, W16 uniquely promoted(beneficial for bone mineral density). Metabolomic profiling revealed pre- and post-fermentation differences in. DISCUSSION: Postbiotic W16 promotes bone growth via regulating growth-related genes, IGF-1 signaling, and gut microbiota. Safer than hGH (no insulin resistance), W16 is a promising functional food candidate for improving short stature in children.
Affiliation
Ziyi Liu
External References
- PubMed ID:
- 42057794
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.