Boric acid exhibits toxicity in trout and zebrafish embryos.
The response of trout and zebrafish embryos to low and high boron concentrations is U-shaped.
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Key Findings
Abstract
Fish in the embryo-larval stage of development have been shown to be sensitive to boron (B) at both ends of the dose-response curve (1,2). The present study evaluated the health effects of low and high B concentrations on rainbow trout (Oncorhynchus mykiss), a cold water species, and zebrafish (Danio rerio), a warm water species. Rainbow trout embryos were incubated from day 1 until 2 wk posthatch in Type 1 ASTM ultrapure-grade water (12.5 degrees C) supplemented with only B (0-500 microM) as boric acid, or together with CaCO3 (0-2 mM) to increase water hardness. Embryonic growth was stimulated by B in a dose-dependent manner at all Ca concentrations (p
Affiliation
Department of Environmental Health Sciences, University of California, Los Angeles 90095-1772, USA.
External References
- PubMed ID:
- 10050924
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