Butyl-p-aminobenzoate. Preparation, characterization and quality control of a suspension injection for epidural analgesia.
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Abstract
The conditions for the preparation of a 10% butyl-p-aminobenzoate suspension for epidural administration were investigated. Pharmaceutically acceptable suspensions are composed of butyl-p-aminobenzoate particles dispersed in a solvent consisting of the surfactant polysorbate 80 added to normal saline in a concentration of 0.25 mg/ml. pH Correction is not necessary. The suspensions are sterilized at 120 degrees C followed by special milling procedures to accomplish acceptable particle size. Butyl-p-aminobenzoate suspensions are stable at 4 degrees C during a period of at least four weeks.
Affiliation
Hospital Pharmacy, Catharina Hospital, Eindhoven, The Netherlands.
External References
- PubMed ID:
- 2034514
- DOI:
- 10.1007/BF01963878
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