Chinese skullcap contains a compound known as baicalin which has protective effects on infective brain edema in rats caused by the injfection of pertussis bacilli.
[Protective effects of baicalin, mannitol and dexamethasone on infective brain edema in rats].
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Abstract
OBJECTIVE: To compare the therapeutic effects of baicalin, mannitol and dexamethasone on infective brain edema(IBE) in rats. METHODS: Forty normal Sprague-Dawley(SD) rats (200 +/- 30) g by weight were divided into 5 groups randomly: (1) normal saline control group(NS, n = 8); (2) infective brain edema group (BE, n = 8); (3) mannitol treatment group(MAN, n = 8); (4) dexamethasone treatment group(DXM, n = 8); and (5) baicalin treatment group(BC, n = 8). Pertussis bacilli(PB, contained bacilli in 10.8 x 10(9), 0.2 ml-1.kg-1) were injected into the left carotid arteries through the left common carotid arteries by puncture to obtain BE models. The contents of brain water, sodium ion, potassium ion and Evans blue in brain tissues were observed too. RESULTS: The contents of brain water, sodium ion, and EB in BE group were higher than those in BE group(P
Affiliation
Department of Pediatrics of Xiangya Hospital, Hunan Medical University, Changsha 410008.
External References
- PubMed ID:
- 12212190
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