The cholinesterase inhibitor drugs may increase tremor and exacerbation of Parkinson's disease.
Cholinesterase inhibitors: tremor and exacerbation of Parkinson's disease.
AI Summary
Key Findings
Abstract
(1) Three cholinesterase inhibitors are marketed in France for the treatment of Alzheimer's disease: donepezil, galantamine and rivastigmine. Tremor and dystonia are known adverse effects of cholinesterase inhibitors. (2) In patients with Parkinson's disease who have cognitive disorders, or in patients with Lewy body dementia, exacerbations of parkinsonism and tremor have been observed during treatment with cholinesterase inhibitors at normal doses. The disorders were reversible on withdrawal of the cholinesterase inhibitor. (3) Withdrawal of cholinesterase inhibitors should be considered if gait disorders, falls or parkinsonism occur or worsen during treatment.
External References
- PubMed ID:
- 17926835
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.