Cinnamon (Cinnamomum cassia) hot water extract improves inflammation and tight junctions in the intestine in vitro and in vivo.
Cinnamon () hot water extract improves inflammation and tight junctions in the intestine in vitro and in vivo.
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Abstract
UNLABELLED: The natural byproductwas widely used in ancient Asia to cure disease because of its various pharmacological effects. Despite its ethnomedicinal benefits, few studies on the intestinal anti-inflammatory effect ofhave been reported. Therefore, this study aimed to evaluate the potential beneficial effects ofon the intestine in vitro and in vivo. Herein, the effects of cinnamon hot water extract (CWE) on tight junction (TJ) barrier function, transepithelial electrical resistance, and mRNA expression were confirmed in Caco-2 cells. The CWE treatment groups showed significantly enhanced cell permeability, proinflammatory cytokine mRNA expression, and TJ expression. CWE-treated mice showed an improved histological index and decreased cytokine concentrations compared with those of colitis model mice. These results suggest that CWE alleviated inflammatory damage and improved the TJ barrier, indicating that CWE may be used as a functional food to improve intestinal health. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10068-023-01292-3.
Affiliation
Tae Gwon Park
External References
- PubMed ID:
- 37781063
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