Research Abstract
Circadian variation of the streptozotocin-diabetogenic effect in mice.
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Key Findings
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Abstract
Streptozotocin was injected in normal mice every 4 h, during the day. Greatest number of diabetic animals were obtained at 16.00 h (95%) and lowest at 08.00 h (50%). Magnitude of hyperglycemia also showed similar distribution. This effect might be considered when planning its use for both experimental and clinical purposes.
External References
- PubMed ID:
- 158539
- DOI:
- 10.1007/BF01963323
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