Research Abstract
Circulating immune complexes in acute uveitis: a possible association with the histocompatibility complex locus antigen B27.
Andrews BS, McIntosh J, Petts V, Penny R
International archives of allergy and applied immunology
Jan 1, 1979
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Abstract
39 patients with acute anterior uveitis were investigated for the presence of circulating immune complex (IC) and correlation with the major histocompatibility complex antigen B27 (HLA-B27). ICs were demonstrated by a number of techniques including rheumatoid factor, complement (C) activation, anticomplementary activity, cryoglobulins, inhibition of IgG-EA rosette formation and neutrophil chemotactic index (NCI) in plasma. ICs were most frequently detected in HLA-B27-negative patients. These results indicate that deposition of circulating ICs may be involved in the pathogenesis of acute anterior uveitis, especially in HLA-B27-negative patients.
External References
- PubMed ID:
- 154477
- DOI:
- 10.1159/000232207
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