Citicoline modulates inflammatory signaling pathways in the spleen of rats exposed to gamma-radiation.
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Key Findings
Abstract
BACKGROUND AND AIM: The spleen has an essential role in immune responses regulation and is considered the biggest peripheral immune organ. Citicoline is used for various brain disorders management. This study aimed to examine the using possibility of citicoline to treatγ-radiation-induced splenic inflammation in rats. MATERIALS AND METHODS: Eighteen male albino rats were classified into: Group 1 (control) animals were kept as control. Group 2 (γ-radiation) animals were total-bodyγ-irradiated with 6 Gy. Group 3 (γ-radiation + citicoline) rats wereγ-irradiated with 6 Gy, then injected intraperitoneally with citicoline (300 mg/kg/d) 5 min after irradiation for one week. Levels of TNF-α, IL-1β, iNOS, NF-κB, JAK2, and STAT3 were determined in spleen tissue, along with histopathological examination. RESULTS: Rats exposure to gamma-radiation led to elevation in splenic TNF-α, IL-1β, NF-κB, iNOS, JAK2, and STAT3 levels significantly. Treatment with citicoline after gamma-radiation exposure improved this elevation, and modulated gamma-radiation-induced histopathological alterations. CONCLUSIONS: This data showed that citicoline inhibitedγ-radiation-induced splenic inflammationsuppressing NF-κB and JAK2/STAT3 signaling pathways in spleen tissue.
Affiliation
Nahed Abdel-Aziz
External References
- PubMed ID:
- 39049671
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