Citrus extract protects against gamma irradiation induced toxicity in bone marrow cells.
Radioprotective effects of citrus extract against gamma-irradiation in mouse bone marrow cells.
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Key Findings
Abstract
The radioprotective effects of citrus extract were investigated by using the micronucleus test for anticlastogenic and cell proliferation activity. A single intraperitoneal (i.p.) injection of citrus extract (Citrus aurantium var. amara) at 250, 500, 1000 mg/kg body weight 1 h prior to gamma-ray irradiation (1.5 Gy) reduced the frequencies of micronucleated polychromatic erythrocytes (MnPCE(S)) and normochromatic erythrocytes (MnNCE (S)). All three doses of citrus extract significantly reduced the frequencies of MnPCEs and MnNCEs in mice bone marrow compared to non-drug-treated irradiated control (p
Affiliation
Department of Medicinal Chemistry, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Tehran, Iran. [email protected]
External References
- PubMed ID:
- 14646227
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