A combination of Cissus quadrangularis and Boswellia serrata extracts promotes the healing of distal radius fractures.
CL16019, A Combination ofandExtracts Promotes the Healing of Distal Radius Fractures: A Multicentric, Randomized, Open-Label Study.
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Abstract
OBJECTIVE: Distal radius fracture (DRF) is the most frequent injury to the upper limb. Complications include nonunion, wrist stiffness and instability, local discomfort, and tendon irritation. The purpose of the current open-label clinical study was to evaluate the safety, efficacy, and tolerability of CL16019, an herbal formulation ofandextract, in accelerating fracture healing in volunteers with DRFs. METHODS: Fifty participants (both male and female; age: 30-50 years) with type I, IIA, or IIB DRFs (as per Lidstrom classification) were equally randomized and treated with standard treatment (ST) or ST + CL16019 for 60 days. The primary efficacy outcome was the radiographical bone fracture healing rate as scored by the Radius Union Scoring System (RUSS). Pain, swelling, and tenderness were among the clinical characteristics evaluated using the visual analog scale (VAS). Wrist function improvements were assessed using the Patient-Rated Wrist Evaluation Questionnaire (PRWEQ). The intergroup and intragroup results were analyzed using a pairedtest and an analysis of covariance model, respectively. RESULTS: The RUSS scores for the ST and ST + CL16019 groups at the end of the trial were 5.54±1.77 and 7.96±0.20, respectively, with a-value
Affiliation
Anjaneya Venkata Vara Prasad Mungara
External References
- PubMed ID:
- 41896193
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