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Research Abstract In Vitro Study

Compounds commonly used as preservatives in US licensed vaccine/biological preparations exhibit significant toxicity and may not comply with the US Code of Federal Regulations for preservatives.

The relative toxicity of compounds used as preservatives in vaccines and biologics.

Med Sci Monit
Apr 28, 2010
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Abstract

BACKGROUND: In vaccines/biologics, preservatives are used to prevent microbial growth. MATERIAL/METHODS: The present study examined: (1) the comparative toxicities of commonly used preservatives in US licensed vaccines to human neurons; and (2) the relative toxicity index of these compounds to human neurons in comparison to bacterial cells. RESULTS: Using human neuroblastoma cells, the relative cytotoxicity of the levels of the compounds commonly used as preservative in US licensed vaccines was found to be phenol

Affiliation

CoMeD, Inc., Silver Spring, MD, USA.

External References

PubMed ID:
20424565

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