Research Abstract
[Diagnosis of Fanconi's anemia by nitrogen mustard induction of chromosome breakage in fibroblasts].
AI Summary
Key Findings
0:00 / 0:00
0:00 / 0:00
Abstract
Induction by nitrogen mustard of chromosome breakage in fibroblasts is proposed as an antenatal test for the diagnosis of Fanconi syndrome. After trypsinization of fibroblasts, addition to the culture medium of 0.025 micrograms/ml nitrogen mustard significantly increased chromosomal breaks in cells from patients with Fanconi syndrome but not in cells from controls. This protocol may prove useful for the antenatal diagnosis of Fanconi syndrome.
Affiliation
Laboratoire de Biologie Clinique, Hôpital du Val-de-Grâce, Paris, France.
External References
- PubMed ID:
- 2017342
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.