Early divergence of erythroid lineage suggested by gene rearrangements in mouse hematopoietic neoplasms.
AI Summary
Key Findings
Abstract
A total of 113 primary murine hematopoietic neoplasms, including those of erythroid, granulocytic, and T and B lymphoid lineages, were examined for rearrangement of immunoglobulin heavy (IgH) and kappa light chain (IgK) and T cell receptor beta and gamma (TcR-beta and TcR-gamma) genes. There was a total absence of Ig or TcR gene rearrangements in erythroid leukemias. In contrast, overlaps of IgH rearrangements were observed in myeloid and T cell as well as B cell neoplasms. In a minority of B cell lymphomas, rearrangements of TcR-beta or TcR-gamma genes were detected. This evidence of shared recombinase activity for myeloid, T cell, and B cell-lineage tumors and the absence of such activity in erythroid tumors suggest early divergence of the erythroid pathway.
Affiliation
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
External References
- PubMed ID:
- 8425572
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