Effect of 12 weeks yoga therapy on heart rate variability and baroreflex sensitivity in female hypothyroid patients.
Effect of 12 Weeks Yoga Therapy on Heart Rate Variability and Baroreflex Sensitivity in Female Hypothyroid Patients: A Randomised Control Trial.
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Abstract
BACKGROUND: Thyroid hormones tend to regulate the metabolic rate of the body. The autonomic nervous system (ANS) is involved in the regulation of cardiovascular functions, and its dysfunction increases cardiovascular risk. About 65% of overt hypothyroid patients have autonomic dysfunction, which is due to sympathetic overactivity and parasympathetic withdrawal leading to a state of sympathovagal imbalance. Also, hypothyroidism is stated to be an independent risk factor for cardiovascular disease. PURPOSE: Yoga practice helps in better modulation of the ANS and has been shown to improve autonomic function in diabetes and heart failure patients. Pranayama has been shown to improve cardiac autonomic function in hypothyroidism. Therefore, we aimed to assess the effect of three months of yoga therapy on autonomic functions in female hypothyroid patients on levothyroxine supplementation. METHODS: In this randomised open-label study, 99 hypothyroid women between the age groups of 18-50 years were recruited from the Endocrinology OPD in JIPMER and were randomly allocated to two groups. The study group subjects (= 51) were administered three months of yoga therapy in addition to levothyroxine supplementation and a control group subjects (= 48) received levothyroxine supplementation only. Autonomic function test parameters such as heart rate variability (HRV) and baroreflex sensitivity (BRS) were recorded at the baseline and after three months of study period in all the participants, and the parameters were compared between the groups and within the groups. HRV was measured from RR tachogram using Biopac MP150 and BRS was assessed using Finapres. RESULTS: After three months of yoga therapy in female hypothyroid patients on levothyroxine supplementation, HRV parameters showed a significant increase in parasympathetic tone (SDNN:= .002, RMSSD:= .021, NN50:
Affiliation
Jayabal Karthiga
External References
- PubMed ID:
- 41063925
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