[Effect of muscular relaxants and anesthetic fluothane on activity of Ca2+-dependent ATPase of skeletal muscle sarcolemma].

Abstract

Ca2+-ATPase of rats and rabbits skeletal muscle sarcolemma was studied as affected by relaxants: tubocurarine, myorelaxin and dioxonium, and by anesthetic fluothane in experiments in vitro and in vivo with lung artificial ventilation during curarization. The musclular relaxant, myorelaxin and anesthetic fluothane both in the experiments in vitro and in vivo inhibited the activity of the enzyme, dioxonium under these conditions caused no significant changes. Tubocurarin in vitro activated the enzyme and in vivo, vice versa, induced inhibition of the enzymic activity. The latter evidences for a many-sided character of the tubocurarine metabolic effect in the living organism. Combination of tubocurarine with fluothane had a less pronounced inhibitory effect on the activity of Ca2+-ATPase than the components used separately.