Research Abstract
[Effect of nicotine on insulin secretion in the isolated perfused rat pancreas].
Chapal J, Loubatières-Mariani MM
Comptes rendus des seances de la Societe de biologie et de ses filiales
Jan 1, 1978
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Abstract
Insulin secretion induced by glucose (1.5 g/l) is changed by nicotine infusion; the recorded changes depend on the nicotine concentration uses. 1) At a low concentration (0.05 mM) nicotine provokes an immediate, progressively increasing and lasting stimulation of insulin secretion. This stimulation is inhibited by hexamethonium (0.1 mM) and atropine (0.3 micrometer). 2) At a high concentration (1 mM) nicotine has a triphasic effect on insulin secretion : brief decrease, peak of stimulation and prolonged decrease. Hexamethonium decreases the stimulation and suppresses the prolonged inhibition.
External References
- PubMed ID:
- 150886
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