Research Abstract
[Effects of chlorpromazine on hypertension by desinhibition in dogs: comparison of intravenous and intracisternal administration].
Montastruc JL, Moreno-Gonzalez A, Cotonat J
Comptes rendus des seances de la Societe de biologie et de ses filiales
Jan 1, 1978
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Abstract
The tensional effects of intravenous and intracisternal chlorpromazine were studied in neurogenic hypertensive dogs by desinhibition and bilateral vagotomy. Intravenous (2-5 mg/kg) chlorpromazine corrected instantaneously the rise in blood pressure after desinhibition, but was inactive on tachycardia. Intracisternal (0.5-2 mg/kg) chlorpromazine was always inactive in the desinhibited dog. These results exclude an intervention from baro -- or chemo -- receptors and central sympathetic structures (alpha adrenergic or dopaminergic receptors). They show that the hypotensive effect of chlorpromazine is a peripheral mechanism.
External References
- PubMed ID:
- 157215
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