Efficacy of Curcuma longa in relieving pain symptoms of knee osteoarthritis patients.
Efficacy ofin relieving pain symptoms of knee osteoarthritis patients: a systematic review and meta-analysis of clinical trials.
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Abstract
OBJECTIVE: Osteoarthritis (OA), particularly knee OA, affects 24% of adults and is a significant cause of disability. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used but have many adverse effects. Antioxidant and anti-iflammatory properties ofmight decrease pain thus improving joint function. METHODS: This systematic review and meta-analysis evaluated randomized controlled trials (RCTs) onefficacy for knee OA. We reported mean differences (MD) with 95% confidence interval (CI) for continuous outcomes and evaluated Visual Analog Scale (VAS) for pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) total score over 4 to 6 weeks for treatment effects. RESULTS: Ten RCTs with 786 patients were included.significantly improved VAS for pain than placebo (MD 18.25, 95% CI 7.79 to 28.72, p=0.0006). It was not inferior to NSAIDs in WOMAC total score improvement (MD -11.99, 95% CI -39.21 to 15.23, p=0.39). Both dosages (
Affiliation
Rudy Hidayat
External References
- PubMed ID:
- 39712249
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