The efficacy of hesperidin in the reduction of atherosclerosis.
The Efficacy of Hesperidin in the Reduction of Atherosclerosis in ApoEMice and Its Possible Mechanism of Action.
AI Summary
Key Findings
Abstract
Atherosclerosis (AS) currently lacks fully effective treatments. This study investigated the natural compound hesperidin as a potential therapy. Apolipoprotein E knockout (ApoE) mice were used as a model of atherosclerosis; we found that hesperidin treatment improved physiological and metabolic health, reduced plaque formation, and decreased systemic inflammation and oxidative stress. Hesperidin also reshaped gut microbiota, increasing beneficial bacteria (and) and significantly lowering fecal levels of branched-chain amino acids (BCAAs: valine, leucine, and isoleucine) by 27.4%, 50.1%, and 40.8%, respectively. These changes were linked to specific microbial shifts. We conclude that hesperidin alleviates atherosclerosis likely by modulating the gut microbiota-BCAA-host axis, identifying it as a promising dietary intervention or therapeutic agent.
Affiliation
Qi Wang
External References
- PubMed ID:
- 41154096
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.