Elevated gliadin antibody levels have been confirmed in individuals with schizophrenia.
Elevated gliadin antibody levels in individuals with schizophrenia.
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Key Findings
Abstract
Objectives. We aimed to replicate, in a larger sample and in a different geographical location, the previously reported elevation of anti-gliadin IgG antibodies in schizophrenia. Methods. A total of 950 adults with schizophrenia (severity assessed by PANSS) and 1000 healthy controls were recruited in the Munich metropolitan area. Anti-gliadin IgG antibodies were analyzed with ELISA.χ(2)-tests and logistic regression were used to analyze the association of schizophrenia with elevated anti-gliadin IgG. A multivariable general linear model was used to compare anti-gliadin IgG levels between patients and controls. Results. The odds ratio of having elevated anti-gliadin IgG antibodies in the schizophrenia group was 2.13 (95% CI 1.57 to 2.91, p
Affiliation
Mood and Anxiety Program, University of Maryland School of Medicine , Baltimore , MD USA.
External References
- PubMed ID:
- 23282016
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