Emodin employs a multi-target mechanism against MRSA and can resensitize the bacterium to conventional β-lactam antibiotics.
The Mechanism of Emodin Against Methicillin-ResistantInfection and Research on Synergistic Antibiotics.
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Key Findings
Abstract
Methicillin-resistant(MRSA) poses a significant clinical challenge due to its multidrug resistance, particularly toβ-lactam antibiotics. This study comprehensively evaluated the natural compound emodin for its anti-activity, mechanisms of action, and potential for synergy withβ-lactam antibiotics. Our findings demonstrate that emodin dose-dependently inhibitsgrowth and abrogates biofilm formation at 2×MIC. Mechanistic studies revealed that emodin compromises cell membrane and wall integrity, induces oxidative stress, and downregulates the virulence factors SPA and EsxA. Furthermore, emodin acted synergistically withβ-lactam antibiotics: it enhanced the ability of cefalexin to block bacterial adhesion and invasion of HaCat cells, and potentiated the efficacy of amoxicillin in clearingfrom infected macrophages. In conclusion, emodin employs a multi-target mechanism againstand can resensitize the bacterium to conventionalβ-lactam antibiotics, presenting a promising strategy for combination therapy that may help curb antibiotic use and resistance development.
Affiliation
Chenliang Chu
External References
- PubMed ID:
- 41465858
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