Exercise protects bone marrow cells following exposure to radiation.
Exercise-induced protection of bone marrow cells following exposure to radiation.
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Key Findings
Abstract
The hormetic effects of exercise training have previously been shown to enhance cellular protection against oxidative stress. Therefore, adaptations to exercise training may attenuate the harmful effects of radiation induced by oxidative stress. Flow cytometric analysis of genotoxicity (γH2AX foci and micronucleated reticulocytes (MN-RET)) and cytotoxicity (apoptosis and percentage of reticulocytes) were conducted on bone marrow cells isolated from acutely exercised (Acute EX), exercise-trained (EX), and sedentary (SED) mice following 1 and 2 Gy radiation challenges in vitro. Acute EX increased the percentage of cells with activated caspase-3 and -7 (32%, p
Affiliation
Department of Kinesiology, McMaster University, Hamilton, ON L8S 4K1, Canada.
External References
- PubMed ID:
- 21326381
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