The findings suggest that apple cider vinegar, might prove to be a beneficial nutraceutical & provide a protective effect against Alzheimer's disease.
Neuroprotective Efficacy of Apple Cider Vinegar on Zinc-High Fat Diet-Induced Mono Amine Oxidase Alteration in Murine Model of AD.
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Key Findings
Abstract
OBJECTIVE: Monoamine Oxidase (MAO), which catalyzes the oxidative deamination of amines present in the brain and peripheral tissues, is involved in the metabolism of monoamines and is vital for cognition. This study was designed to examine the protective effect of Apple Cider Vinegar (ACV) on MAO and amine neurotransmitters such as dopamine (DA), serotonin (5-HT), non-adrenaline (NA) levels. METHOD: In this experiment, out of five groups, three groups of animals were pretreated with one of the test drugs each i.e., Chrysin (10 mg/kg), ACV (0.7% v/v) and Rivastigmine (2.5 mg/kg) along with Zn with high fat diet (HFD) for 3 months and the rest two groups were that of control and disease induced. After the treatment period, mice were examined for MAO-A&B, DA, 5-HT and NA level estimation. RESULTS: The results showed that Zn with HFD had induced a significant increase (
Affiliation
Smriti Tripathi
External References
- PubMed ID:
- 34323669
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