Fruit and vegetable intake and dietary intake of vitamin C may contribute to reducing the risk of disabling dementia.
Fruit and vegetable intake and risk of disabling dementia: JPHC Disabling Dementia Study.
AI Summary
Key Findings
Abstract
BACKGROUND: Fruits and vegetables contain abundant amounts of antioxidant vitamins such as vitamin C,α-carotene, andβ-carotene. Few prospective observational studies have investigated the effects of fruit and vegetable intake on the risk of dementia, and the results are inconsistent. OBJECTIVE: Our aim was to examine associations between fruit and vegetable intakes and the risk of disabling dementia. METHODS: We conducted a follow-up survey within the Japan Public Health Center-based Prospective Study involving 42,643 individuals aged 50 to 79 years at baseline (2000-2003). Dietary fruit and vegetable intakes, and related antioxidant vitamin intakes (i.e.,α-carotene,β-carotene, and vitamin C) were determined using a food frequency questionnaire. The diagnosis of disabling dementia was made based on the daily living disability status related to dementia under the Japanese long-term care insurance program from 2006 to 2016. Hazard ratios and 95% confidence intervals for disabling dementia were estimated using area-stratified Cox proportional hazard models adjusted for potential confounding factors. RESULTS: A total of 4,990 cases of disabling dementia were recorded. We observed an inverse association between total fruit and vegetable intake and the risk of dementia among men and women: the multivariate hazard ratios (95% confidence intervals) for the highest versus lowest quartiles of intake were 0.87 (0.76, 0.99)(P for trend = 0.05) among men, and 0.85 (0.76, 0.94)(P for trend = 0.006) among women. Among antioxidant vitamins, vitamin C intake was inversely associated with the risk of dementia among men and women: the multivariate hazard ratios (95% confidence intervals) for the highest versus lowest quartiles of intake were 0.71 (0.61, 0.84)(P for trend
Affiliation
Rie Kishida
External References
- PubMed ID:
- 38599388
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.