Full-fat rice bran ameliorates insulin resistance and modulates muscle-related parameters in high-fat diet-fed ovariectomized mice.
Full-Fat Rice Bran Ameliorates Insulin Resistance and Modulates Muscle-Related Parameters in High-Fat Diet-Fed Ovariectomized Mice with Potential Involvement of the Gut-Muscle Axis.
AI Summary
Key Findings
Abstract
The study aimed to evaluate the effects of full-fat rice bran (FFRB; Tainung No. 81, Taiwan) at various doses on insulin resistance, muscle atrophy, and gut microbiota composition in middle-aged ovariectomized (OVX) mice fed a high-fat diet (HFD), using young sham-operated mice as a life-stage reference group.Thirty-six female ICR mice were assigned to six groups, including OVX mice fed HFD with or without 5%, 10%, or 20% FFRB.Compared with HFD-fed OVX controls, 20% FFRB reduced body weight gain by 43%, decreased visceral fat mass, and improved insulin resistance (homeostasis model assessment of insulin resistance, HOMA-IR reduced by 65%,= 0.001). FFRB attenuated the decline in relative grip strength (forelimb,= 0.013; four-limb,
Affiliation
Pei Yu Loe
External References
- PubMed ID:
- 42280417
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.