Garlic extract is effective in preventing aflatoxin-induced toxicity and free radical generation in rats.

Abstract

The present study evaluated the protection role of garlic, cabbage, and onion extracts against the toxic effects of aflatoxin. One hundred and twenty mature male Sprague-Dawley rats were randomly assigned to eight experimental groups and treated for 15 days with extracts with or without aflatoxin. Blood samples were collected from all animals from the retro-orbital venous plexus at the end of the experimentation period for biochemical analysis. Livers and kidneys were removed at the end of the treatment period for determination of glutathione, malondialdehyde, and superoxide dismutase. The results indicated that animals treated with aflatoxin showed significant signs of aflatoxicosis. Extracts alone had insignificant effects on all parameters tested, whereas cotreatment with aflatoxin and extracts resulted in a significant improvement in all parameters; moreover, garlic extract was found to be the most effective in the prevention of aflatoxin-induced toxicity and free radical generation in rats.