Gene expression profiles modulated by lipophilic sea buckthorn extract in BT-549 triple-negative breast cancer cells.
Gene Expression Profiles Modulated by Lipophilic Sea Buckthorn (L.) Extract in BT-549 Triple-Negative Breast Cancer Cells.
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Key Findings
Abstract
Triple-negative breast cancer (TNBC) is an aggressive subtype with high heterogeneity, metastasis, and drug resistance, underscoring the need for new therapeutic strategies. Sea buckthorn berries, long used in traditional medicine, are rich in carotenoids with reported anticancer activity. To investigate their transcriptional effects, we treated BT-549 TNBC cells with a saponified lipophilic sea buckthorn berry extract (LSBE) and performed gene expression profiling using microarray (four independent replicates of treated, respectively, untreated cells). LSBE altered the expression of 330 protein-coding genes (111 downregulated, 219 upregulated; fold ratio±1.5, adj.
Affiliation
Simona Visan
External References
- PubMed ID:
- 41409192
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