Globimetula braunii has oxytocic properties supporting is traditional use in hastening delivery in traditional medicine practice.
Oxytocic properties of the aqueous extract of Globimetula braunii (loranthaceae).
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Key Findings
Abstract
The leaves of Globimetula braunii are used in ethnomedicine to augment labour. The crude aqueous extract of the plant was tested on isolated rat uteri. The agonistic activity of the aqueous extract was compared with that of a standard uterine stimulant oxytocin and uterine smooth muscle antagonists atropine and salbutamol. The extract was found to exhibit oxytocic activity on the uterine smooth muscle which was less potent than that of oxytocin. The force of contraction (3.60 +/-0.25 g) elicited by the highest concentration of the extract (640 mg/ ml) was similar to that of 2.7 x 10-4 mg / ml of oxytocin (3.61+/-0.17 g). Oxytocin was also observed to significantly (p
Affiliation
Department of Pharmacognosy and Department of Pharmacology, Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, Nigeria. [email protected]
External References
- PubMed ID:
- 18930855
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