Gluten exorphin modulate pancreatic endocrine function by stimulating insulin release.
Effect of gluten exorphins A5 and B5 on the postprandial plasma insulin level in conscious rats.
AI Summary
Key Findings
Abstract
The effect of exogenous opioid peptides, gluten exorphins A5 and B5, which were isolated from the enzymatic digest of wheat gluten, on the postprandial insulin level were examined in rats. The oral administration of gluten exorphin A5 at a dose of 30 mg/kg w. potentiated the postprandial plasma insulin level and the effect was reversed by naloxone. The administration of gluten exorphin B5 showed a similar effect at a higher dose (300 mg/kg w). Furthermore, intravenous administration of gluten exorphin A5 at a dose of 30 mg/kg w. also stimulated the postprandial insulin release. The fact that orally and intravenously administered gluten exorphin A5 stimulates insulin release suggests that it modulates pancreatic endocrine function by the action after the absorption rather than within the the gastrointestinal tract.
Affiliation
Research Control Department, Nisshin Flour Milling Co., Ltd., Tokyo, Japan.
External References
- PubMed ID:
- 7637543
Comments
Sign in or create a free account to join the conversation.
Sign in to commentBe the first to comment.