Hesperidin efficacy of epidural fibrosis in a post laminectomy.
Hesperidin efficacy of epidural fibrosis in a post laminectomy rat model: an experimental study.
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Abstract
BACKGROUND/AIM: Epidural fibrosis (EF) plays a significant role in the development of failed back surgery syndrome (FBSS). This study evaluates the antifibrotic effect of hesperidin, a citrus-derived bioflavonoid, within a rat laminectomy model. MATERIALS AND METHODS: Thirty-two female Wistar albino rats were randomized into four groups (n = 8 each). Group 1 received laminectomy alone (control); Group 2 received a gelatin sponge; Groups 3 and 4 intraperitoneally received 50 mg/kg and 100 mg/kg of hesperidin, respectively, for 7 days post-laminectomy. After 6 weeks, epidural tissues were assessed histopathologically, and hydroxyproline levels were measured. RESULTS: Group 4 showed significantly lower EF grades compared with Groups 1 and 2 (p
Affiliation
Emrah Keskin
External References
- PubMed ID:
- 41234465
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