Iminosugar idoBR1 isolated from cucumber Cucumis sativus reduces inflammatory activity.
Iminosugar idoBR1 Isolated from CucumberReduces Inflammatory Activity.
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Key Findings
Abstract
Cucumbers have been anecdotally claimed to have anti-inflammatory activity for a long time, but the active principle was not identified. idoBR1, (2,3,4,5)-3,4,5-trihydroxypiperidine-2-carboxylic acid, is an iminosugar amino acid isolated from fruits of certain cucumbers,(Cucurbitaceae). It has no chromophore and analytically behaves like an amino acid making detection and identification difficult. It has anti-inflammatory activity reducing lipopolysaccharide (LPS)-induced tumor necrosis factor alpha (TNF-α) in THP-1 cells andhuman blood. It showed selective inhibition of humanα-l-iduronidase and sialidases from both bacteria () and human THP-1 cells. idoBR1 and cucumber extract reduced the binding of hyaluronic acid (HA) to CD44 in LPS-stimulated THP-1 cells and may function as an anti-inflammatory agent by inhibiting induced sialidase involved in the production of functionally active HA adhesive CD44. Similar to the related iminosugars, idoBR1 is excreted unchanged in urine following consumption. Its importance in the diet should be further evaluated.
Affiliation
Robert J Nash
External References
- PubMed ID:
- 32656449
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