[Influence of acute and chronic poisoning with dichloroethylene on the kinetics of antibody-forming cells and the plasmocytic reaction in the spleen of rats in immunization with the O-antigen of Sal. typhi].

Abstract

Local hemolysis in gel demonstrated in tests on rats that with its acute action in a concentration of 25 mg/l (1/2 CL50) dichlorethylene stimulates, while with subacute action in a concentration of 5 mg/l--inhibits the formation of cells producing antibodies to the typhoid antigen, as well as the plasmocytic reaction of the spleen following immunization of the O-antigen from Sal. typhi and also without it. In poisoning subject to a dynamic changed is also the number of the antibody forming cells (ABFC) after immunization, viz. their doubling time decreased, with stimulation the antibody formation becames less intensive, whereas with chronic action of the poison the doubling time increases and the dropoff in the number of ABFC gains in speed. It may be presumed that the effect of the poison under study on the immunogenesis is conditioned by the action of the poison on the number of immunologically competent cells-precursors, released for differentiation irrespective of the antigen's action, simultaneously and immediately upon its introduction, as well as on the extent of recruitment, multiple, non-changed passage from the precursors compartment into that of the ABFC, occurring at the level of the integral organism, possibly through the intermidiary of the endocrine and vegetative nervous systems.